ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Thyroid And Parathyroid Diseases And Cardiovascular System
Dr. Beyhan ERYONUCUa
aKardiyoloji ABD, Fatih Üniversitesi Tıp Fakültesi, ANKARA
Thyroid hormone has important effects on the myocardium. Thyroid hormone also has indirect and direct effects on peripheral vascular smooth muscle tone, and alters the function of the left ventricle and arterial system. Cardiovascular manifestations are frequent in thyroid dysfunction and may be result of direct hormone effects at cellular level, interactions with the sympathetic nervous system, or alterations of peripheral circulation and metabolism. It is well established that overt hyperthyroidism induces a hyperdynamic cardiovascular state (high cardiac output with low systemic vascular resistance, faster heart rate, enhanced left ventricular systolic and diastolic function, and increased prevalence of atrial fibrillation, whereas overt hypothyroidism is characterized by the opposite changes.
Amiodarone is a commonly used drug for drug treatment of rhythm disturbances, which can cause either hyper- or hypofunction of the thyroid. The pathophysiology of amiodarone-induced thyroid disease is complex and management can be difficult. Especially, classification of subtypes of amiodarone-induced hyperthyroidism is helpful in guiding therapy.
This article will summarize the clinically important effects of thyroid and parathyroid hormone on cardiovascular function and the diagnosis and management of amiodarone-induced thyroid dysfunction.Keywords: Thyroid diseases; parathyroid diseases; heart; amiodaroneTurkiye Klinikleri J Int Med Sci 2007, 3(33):8-14
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