ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Hypertrophic Cardiomyopathy
Dr. Dilek YEŞİLBURSAa
aKardiyoloji ABD, Uludağ Üniversitesi Tıp Fakültesi, BURSA
Hypertrophic cardiomyopathy (HCM) is a genetic disease caused by specific gene mutations in the genes encoding cardiac sarcomer proteins. The pathophysiology of this disease is diverse, with variable patterns and severity of left ventricular hypertrophy, diastolic dysfunction, mitral regurgitation, left ventricular outflow tract obstruction, and arrhythmias. There is a wide heterogeneity in pathophysiology as well as clinical presentation. Some patients remain completely asymptomatic and lead a normal lifespan, while others have severe limiting symptoms of dyspnea, angina, syncope and/or sudden cardiac death. The treatment of HCM has been divided into pharmacologic therapy versus more invasive procedures (dual-chamber pacing, catheter-based septal ablation, and septal myectomy in obstructive HCM). Implantable cardiac defibrillators are considered a treatment option in individuals with HCM who are at risk for sudden cardiac death.Keywords: Cardiomyopathy, hypertrophic; therapyTurkiye Klinikleri J Int Med Sci 2007, 3(24):4-10
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